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Gender: Male
Birthday year: 1967
Nationality: Taiwan
Current working Address:
Department of Anesthesiology, No 138 Sheng Li Road, National Cheng Kung University Medical College and Hospital, Tainan city 704, Taiwan
Education:
 Ph.D. National Sun Yat-Sen University, Kaohsiung, Taiwan 2001-2010
M.S, Physiology, Tzu Chi University, Hualien, Taiwan 1998-2000
M.D., National Yang Ming University, Taiwan 1987-1994
Current Position:
Associate Professor, Department of Anesthesiology, National Cheng-Kung University, Taiwan 2010-
Director, Basic Anesthesia Research, Department of Anesthesiology, National Cheng-Kung University Hospital, Taiwan 2015-
Managing Supervisor, Taiwan Pain Society 2015-
Supervisor, Taiwan Society of Anesthesiologists 2014-
Director, Research development and promotion committee, Taiwan Society of Anesthesiologists 2014-
Vice Director, Specialist Accreditation committee, Taiwan Society of Anesthesiologists 2012-
Editorial Board, Taiwan Society of Anesthesiologists 2015-
Editor-in-Chief, The Taiwan Journal of Pain 2016-
Experience:
Director, Department of Anesthesiology, National Cheng Kung University medical school and Hospital, Taiwan, 2011-2015
Assistant Professor, Department of Anesthesiology, National Cheng Kung University, Taiwan, 2004-2010
Research fellow, Department of Anesthesiology, Brigham and Women’s Hospital, Harvard university, Boston, USA 2008-2010
Visiting Staff, Department of Anesthesiology, Kaohsiung Veteran General Hospital, Taiwan 2000 – 2004
Attending, Yu-Li Veteran Hospital, Hualien County, Taiwan. 1998-2000
Director, Quality and Safety committee, Taiwan Society of Anesthesiologists 2012-2014
Vice Director, Education committee in south Branch, Taiwan Society of Anesthesiologists 2012-2014
Secretary General, Taiwan Pain Society 2006-2008，2013-2015
Supervisor, Taiwan Pain Society 2012-2014
Director, Taiwan Society of Anesthesiologists 2012-2014
Proposition for High Special Technicians, Ministry of Examination, Taiwan 2015
Research Award:
Elite Aboard Research Program for the staffs in National Cheng Kung University Hospital 2008
The CASP Young Investigator Award, Chinese Association for the Study of Pain, CASP (Taiwan), 2010
Top 15 Basic Research Poster, Annual meeting of Taiwan society of Anesthesiologists, 2010
The CASP Research Prize, Chinese Association for the Study of Pain, CASP (Taiwan), 2011
Field of Research Interesting:
Anesthesiology (anesthetics on pathological conditions)
Pain medicine (opioid and other analgesics)
Physiology (pain on physiological impact)
Journal Reviewer :
Acta Anaesthesiologica Taiwanica
The Chinese Journal of Pain (Taiwan)
Kaohsiung Journal of Medical Sciences
Journal of Microbiology, Immunology and Infection
TZU CHI Medical Journal (Taiwan)
Evidence-Based Complementary and Alternative Medicine
Case Reports in Anesthesiology
Oxidative Medicine and Cellular Longevity
Pain Medicine
Journal of Pharmacological Sciences
Conference Moderator/ Speaker:
Annual Meeting of the Taiwan Pain Society
Annual Meeting of the Taiwan Society of Anesthesiologists
Asian Australasian Federation of Pain Societies 2014
Special Seminar of Taichung Veterans General Hospital
Special Seminar of Kaohsiung Medical University
TSA Anesthesia Monthly Meeting in Southern Taiwan
Publication List:
1. Hsiao HT, Lin YC, Wang JCF, Tsai YC, Liu YC. Hypoxia inducible factor-1α inhibition produced anti-allodynia effect and suppressed inflammatory cytokine production in early stage of mouse complex regional pain syndrome model.
Clinical and Experimental Pharmacology and Physiology. 2016 Mar;43(3):355-9. doi: 10.1111/1440-1681.12536
2.Hsiao HT, Wu H, Huang PC, Tsai YC, Liu YC. The effect of propofol and sevoflurane on antioxidants and proinflammatory cytokines in a porcine ischemia-reperfusion model.
Acta Anaesthesiol Taiwan. 2016 Mar;54(1):6-10. doi: 10.1016/j.aat.2015.11.002.
3.Berta T, Park CK, Xu ZZ, Xie RG, Liu T, Lü N, Yen-Chin Liu, Ji RR.
Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion.
J Clin Invest. 2014 Mar;124(3):
4.Berta T+, Yen-Chin Liu+, Xu ZZ, Ji RR
Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1β and ERK signaling in the spinal cord of mice. 2013 Sep
Neuroscience. 2013;247:376-85
5.Tsai YC, Huang CC, Chu LM, Yen-Chin Liu.
Differential influence of propofol on different cell types in terms of the expression of various oxidative stress-related enzymes in an experimental endotoxemia model.
Acta Anaesthesiol Taiwan. 2012 Dec;50(4):159-66. doi: 10.1016/j.aat.2012.11.002
6.Liu T, Berta T, Xu ZZ, Park CK, Zhang L, Lü N, Liu Q, Liu Y, Gao YJ, Yen-Chin Liu , Ma Q, Dong X, Ji RR.
TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice.
J Clin Invest. 2012 Jun;122(6):2195-207
7. Yen-Chin Liu Wu PC, Shieh DB, Wu SN
The effects of magnetite (Fe3O4) nanoparticles on electroporation-induced inward currents in pituitary tumor (GH3) cells and RAW 264.7 macrophages. 2012 Mar
International Journal of Nanomedicine. 2012:7 1687–1696.
8.Hsu CY, Fang SY, Chen YZ, Roan JN, Chang SW, Huang CC, Yen-Chin Liu, Lam CF, Tsai YC.
Cardiovascular protection of activating KATP channel during ischemia-reperfusion acidosis.
Shock. 2012 Jun;37(6):653-8. doi: 10.1097/SHK.0b013e318252caf6.
9. Yen-Chin Liu, Berta T, Liu T, Tan PH,Ji RR.
Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice
Mol Pain. 2012 Mar 25;8(1):19.
10.Berta T, Liu T, Yen-Chin Liu, Xu ZZ,Ji RR.
Acute morphine activates satellite glial cells and up-regulates IL-1beta in dorsal root ganglia in mice via matrix metalloprotease-9.
Mol Pain. 2012 Mar 22;8(1):18
11.Yeh CY, Chung SC, Tseng FL,Tsai YC, Yen-Chin Liu
Biphasic effects of chronic intrathecal gabapentin administration on the expression of protein kinase C gamma in the spinal cord of neuropathic pain rats.
Acta Anaesthesiol Taiwan, 2011 Dec;49(4):144-8.
12. Wen YR, Tan PH, Cheng JK, Yen-Chin Liu, Ji RR.
Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance. 2011 Aug
J Formos Med Assoc.;110(8):487-94.
13. Lam CF, Roan JN, Lee CH, Chang PJ, Huang CC, Yen-Chin Liu, Jiang MJ, Tsai YC
Transplantation of endothelial progenitor cells improves pulmonary endothelial function and gas exchange in rabbits with endotoxin-induced acute lung injury
Anesth Analg. 2011 Mar;112(3):620-7
14. Gao Y J, Z. Z. Xu, ZZ, Yen-Chin Liu, Wen YR, Decosterd I, Ji RR
The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition. 2010 Feb
Pain, 148(2): 309-19.
15. Hsu JK, Wu MF, Tsai YC, Yen-Chin Liu
Intermittent interscalene bolckade can provide long term pain relief in a patient with complex regional pain syndrome. 2009
Chinese J Pain; 19(1)23-28
16. Yen-Chin Liu, Chan JY, Tsai YC
Influence of propofol on blood pressure spectrum in sepsis and the role of inducible nitric oxide synthase 2009 Jun
Acta Anaesthesiol Taiwan.;47(2):62-70
17. Wu SN, Wu YH, Chen BS, Lo YC, Yen-Chin Liu
Underlying mechanism of actions of tefluthrin, a pyrethroid insecticide, on voltage-gated ion currents and on action currents in pituitary tumor (GH3) cells and GnRH-secreting (GT1-7) neurons. 2009 Apr
Toxicology. 5;258(1):70-7
18. Yen-Chin Liu, Wang YJ, Wu PY, Wu SN
Tramadol-induced block of hyperpolarization-activated cation current in rat pituitary lactotrophs. 2009 Feb
Naunyn Schmiedebergs Arch Pharmacol.;379(2):127-35
19.Yen-Chin Liu, Chang AY, Tsai YC, Chan JY
Differential protection against oxidative stress and nitric oxide overproduction in cardiovascular and pulmonary systems by propofol during endotoxemia 2009 Jan
J Biomed Sci. 15;16:8
20. Su MW, Hsu JK, Tsai YC, Yen-Chin Liu. 2008
Ascorbic Acid alleviate hyperbaric oxygen therapy induced pain
Chines J Pain;18(2):71-76
21.Yen-Chin Liu, Wang YJ, Wu SN
The mechanisms of propofol-induced block on ion currents in differentiated H9c2 cardiac cells 2008 Aug
Eur J Pharmacol. 20;590(1-3):93-8
22. Lam CF, Chang PJ, Huang YS, Sung YH, Huang CC, Lin MW, Yen-Chin Liu, Tsai YC
Prolonged use of high-dose morphine impairs angiogenesis and mobilization of endothelial progenitor cells in mice 2008 Aug
Anesth Analg.;107(2):686-92
23. Wu SN, Chen BS, Lin MW,Yen-Chin Liu 2008 Jun
Contribution of slowly inactivating potassium current to delayed firing of action potentials in NG108-15 neuronal cells: experimental and theoretical studies. J Theor Biol. 21;252(4):711-21
24. Lam CF, Yen-Chin Liu, Hsu JK, Yeh PA, Su TY, Huang CC, Lin MW, Wu PC, Chang PJ, Tsai YC 2008 Apr
Autologous Transplantation of Endothelial Progenitor Cells Attenuates Acute Lung Injury in Rabbits
Anesthesiology.;108(3):392-401
25. Yu YC, Feng JY, Yen-Chin Liu, Pan YL, Tsai YC 2007
Psychosocial characteristics are related to the pain intensity in pain clinic patients
Chines J Pain 17(2):48-55
26. Hsu JK, Tsai YC, Hsu CY, Yen-Chin Liu, Yeh CY 2007
Application of Unilateral Sympathectomy in a Patient with Complex Regional Pain Syndrome Type II
Chines J Pain 17(1):25-31
27. Tsai TY, Huang YS, Tsai YC, Yen-Chin Liu.2007 Dec
Temporary femoral nerve palsy after ilioinguinal nerve blockade combined with splash block for post-inguinal herniorrhaphy analgesia in a pediatric patient
Acta Anaesthesiol Taiwan;45(4):237-40
28. Yen-Chin Liu, Kao SJ, Chuang IC, Chen HI. 2007 Nov
Nitric oxide modulates air embolism-induced lung injury in rats with normotension and hypertension.
Clin Exp Pharmacol Physiol.34(11):1173-80. (SCI)
29. Lam CF, Yen-Chin Liu, Tseng FL, Sung YH, Huang CC, Jiang MJ, Tsai YC 2007 Mar
High-Dose Morphine Impairs Vascular Endothelial Function by Increased Production of Superoxide Anions
Anesthesiology. 106(3):532-537 (SCI)
30. Tsai TY, Tsai YC, Wu SN, Yen-Chin Liu. 2006 Oct
Tramadol-induced blockade of delayed rectifier potassium current in NG108-15 neuronal cells.
Eur J Pain. 10(7):597-601 (SCI) (NSC 93-2314-B-006-127- )
31. Yen-Chin Liu, Tseng FL, Feng JY, Lam CF, Tsai YC. 2006 Sep
Pain intensity and barometric pressure closely correlate in Southern Taiwan.
Acta Anaesthesiol Taiwan. 44(3):147-52.
32. Pang YL, Tseng FL, Tsai YC, Yen-Chin Liu. 2006 Sep
Suxamethonium-induced hyperkalaemia in a patient with a normal potassium level before rapid-sequence intubation.
Crit Care Resusc 8(3):213-4.
33. Wang YJ, Yen-Chin Liu, Chang HD, Wu SN 2006 Apr
Diosgenin, a plant-derived sapogenin, stimulates Ca2+-activated K+ current in human cortical HCN-1A neuronal cells.
Planta Med 72(5):430-6. (SCI)
34. Tsai TY, Chang PJ, Chen SH, Yen-Chin Liu, Sung YH, Tsai YC 2006 Mar
Severe bronchospasm during laryngeal mask airway placement in an infant.
Acta Anaesthesiol Taiwan. 44(1):39-42.
35. Huang MH, So EC, Yen-Chin Liu, Wu SN. 2006 Feb
Glucocorticoids stimulate the activity of large-conductance Ca(2+)-activated K(+) channels in pituitary GH(3) and AtT-20 cells via a non-genomic mechanism.
Steroids. 71(2):129-40 (SCI)
36. Yen-Chin Liu, Wu SN 2005 Dec
BAY 41-2272, a potent activator of soluble guanylyl cyclase, stimulates calcium elevation and calcium-activated potassium current in pituitary GH cells.
Clin Exp Pharmacol Physiol.;32(12):1078-87. (SCI)
37. Yeh PA, Chen HP, Tsai YC, Lin YJ, Yen-Chin Liu 2005 Dec
Successful management of air embolism-induced ventricular fibrillation in orthotopic liver transplantation.
Acta Anaesthesiol Taiwan.;43(4):243-6.
38. Tsai TY, Wu SN, Yen-Chin Liu, Wu AZ, Tsai YC. 2005 Oct 31
Inhibitory action of L-type Ca(2+) current by paeoniflorin, a major constituent of peony root, in NG108-15 neuronal cells.
Eur J Pharmacol.;523(1-3):16-24. (SCI)
39. Chen SH, Sung YH, Chang PJ, Yen-Chin Liu, Tsai YC. 2005 Aug
The management of labour using continuous lumbar epidural analgesia with 0.2% ropivacaine in a parturient with traumatic brain injury
Eur J Anaesthesiol;22(8):634-6
40. Lo YC, Yang SR, Huang MH, Yen-Chin Liu, Wu SN. 2005 Apr 1
Characterization of chromanol 293B-induced block of the delayed-rectifier K+ current in heart-derived H9c2 cells.
Life Sci. 76(20):2275-86. (SCI)
41. Huang CW, Huang CC, Yen-Chin Liu, Wu SN. 2004 Jul
Inhibitory effect of lamotrigine on A-type potassium current in hippocampal neuron-derived H19-7 cells.
Epilepsia; 45(7):729-36
42. Chung NC, Yen-Chin Liu, Ye XD, Wang YM, Kuo MC, Liu K. 2003 Dec
Fatal arrhythmia following intraoperative continuous hyperthermic peritoneal perfusion chemotherapy.
Acta Anaesthesiol Sin.;41(4):201-4.
43. Yen-Chin Liu, Lo YC, Huang CW, Wu SN* 2003 Nov
Inhibitory action of ICI-182,780, an estrogen receptor antagonist, on BK(Ca) channel activity in cultured endothelial cells of human coronary artery.
Biochemcal Pharmacology. 15;66(10):2053-63. (SCI)
44. Chan MH, Yen-Chin Liu, Deng BS, Liu K. 2003 Sep
General anesthesia for patients with automatic implantable cardioverter defibrillator in place--a case report.
Acta Anaesthesiol Sin.;41(3):159-62.
45. Wang YR, Yen-Chin Liu, Chung NC, Wu SZ, Chen MS, Ye XD, Liu K
Inferior vena cava tear during posterior spinal fusion surgery
Acta Anaesthesiol Sin 41(2):89-92
46. Wan YM, Yen-Chin Liu, Ye XD, Chia YY, Liu K 2003 Jun
Anesthetic management of laparoscopic surgery in a patient with a ventriculoperitoneal shunt
Acta Anaesthesiologica Sinica 41:85-88,
47. Wu SN, Lin PH, Hsieh KS, Yen-Chin Liu, Chiang HT. 2003 Jan
Behavior of nonselective cation channels and large-conductance Ca2+-activated K+ channels induced by dynamic changes in membrane stretch in cultured smooth muscle cells of human coronary artery.
J Cardiovasc Electrophysiol; 14(1):44-51.
48. Yen-Chin Liu, Wu SN. 2003 Jan
Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH3 cells
European Journal of Pharmacology 458(1-2):37-47, (SCI)
49. Yen-Chin Liu, Lo YK, Wu SN. 2003 Jan
Stimulatory effects of chlorzoxazone, a centrally acting muscle relaxant, on large conductance calcium-activated potassium channels in pituitary GH3 cells
Brain Research 959(1): 86-97, (SCI)
50. Wu SN, Chen H, Yen-Chin Liu, Chiang HT. 2002 Jun
Block of L-type Ca2+ current by beauvericin, a toxic cyclopeptide, in the NG-108-15 neuronal cell line.
Chem Res Toxicol 15(6):854-60, (SCI)
51. Chia YY. Liu K. Yen-Chin Liu. Chang HC. Wong CS. 1998 Jun
Adding ketamine in a multimodal patient-controlled epidural regimen reduces postoperative pain and analgesic consumption.
Anesthesia & Analgesia. 86:1245-9, (SCI).
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